Solid Tumors News

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Checkpoint blockade in solid tumors and B-cell malignancies, with special consideration of the role of CD200 - Dove Medical Press



Checkpoint blockade in solid tumors and B-cell malignancies, with special consideration of the role of CD200 
Dove Medical Press
Abstract: In the ontogeny of a normal immune response, a series of checkpoints must be overcome to ensure that unwanted and/or harmful self-directed activation responses are avoided. Many of the molecules now known to be active in this overseeing of ...

 


Dr. Hong Discusses IPI-549 in Advanced Solid Tumors - OncLive



OncLive
 
Dr. Hong Discusses IPI-549 in Advanced Solid Tumors 
OncLive
David S. Hong, MD, deputy chair, Department of Investigational Cancer Therapeutics, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, discusses IPI-549 during The Society for Immunotherapy of Cancer (SITC) 32nd Annual ...

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ITUS Enters CAR-T Research Alliance with Moffitt Cancer Center - Markets Insider



ITUS Enters CAR-T Research Alliance with Moffitt Cancer Center 
Markets Insider
We are excited to advance this program which we hope will be the first or one of the first CAR-T technologies that shows efficacy for solid tumors. CAR-T technology is a new adoptive cell therapy that has shown tremendous efficacy for refractory cancer ...

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Drug delivery to solid tumors: the predictive value of the multicellular tumor spheroid model for nanomedicine screening - Dove Medical Press



Drug delivery to solid tumors: the predictive value of the multicellular tumor spheroid model for nanomedicine screening 
Dove Medical Press
Abstract: The increasing number of publications on the subject shows that nanomedicine is an attractive field for investigations aiming to considerably improve anticancer chemotherapy. Based on selective tumor targeting while sparing healthy tissue, ...

 


Renal Cell Carcinoma Advisor - Cancer Therapy Advisor



Cancer Therapy Advisor
 
Renal Cell Carcinoma Advisor 
Cancer Therapy Advisor
Unlike with some other solid tumors, there are not many targetable mutations found in renal cell carcinoma (RCC). ?Having biomarkers for prognosis is important, but at the end of the day patients and physicians want to know what we can do differently ...

 


In the lab and in the clinic, alisertib with TAK-228 excels against solid tumors - Science Daily



In the lab and in the clinic, alisertib with TAK-228 excels against solid tumors 
Science Daily
Led by Diamond and presented by first author, CU Cancer Center investigator, S. Lindsey Davis, MD, the phase 1 clinical trial (NCT02719691) of alisertib with TAK-228 in patients with advanced solid tumors opened in 2016. Results presented this weekend ...

 


Daiichi Sankyo Initiates Pivotal Phase 2 Study of DS-8201 in Patients with HER2-Positive Advanced Gastric Cancer - Markets Insider



Daiichi Sankyo Initiates Pivotal Phase 2 Study of DS-8201 in Patients with HER2-Positive Advanced Gastric Cancer 
Markets Insider
Compounds in development include: quizartinib, an oral FLT3 inhibitor, for newly-diagnosed and relapsed or refractory AML with FLT3-ITD mutations; DS-8201, an ADC for HER2-expressing breast and gastric cancer, and other HER2-expressing solid tumors; ...

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FDA OKs Batu Biologics' ValloVax for Clinical Investigation in Certain Solid Tumors - Immuno-Oncology News



Immuno-Oncology News
 
FDA OKs Batu Biologics' ValloVax for Clinical Investigation in Certain Solid Tumors 
Immuno-Oncology News
This is the first immunotherapy targeting the blood vessels feeding tumors to receive an investigational new drug (IND) approval from the FDA. The decision will allow the company to initiate Phase 1 clinical trials testing the drug. ?It has been my ...

 


Celsion Announces Publication of the Study of ThermoDox® + Ultrasound, ?TARDOX Study Protocol? in the Journal of ... - GlobeNewswire (press release)



Celsion Announces Publication of the Study of ThermoDox® + Ultrasound, ?TARDOX Study Protocol? in the Journal of ... 
GlobeNewswire (press release)
... the safety and feasibility of targeted drug release and enhanced delivery of doxorubicin from thermally sensitive liposomes (ThermoDox®) triggered by mild hyperthermia induced by focused ultrasound in primary and metastatic solid liver tumors.

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Tazemetostat Active in Rare Pediatric Solid Tumors - Cancer Network



Tazemetostat Active in Rare Pediatric Solid Tumors 
Cancer Network
Children with relapsed or refractory INI1-deficient malignant rhabdoid tumors, epithelioid sarcomas, or poorly differentiated chordomas tolerated treatment with the investigational drug tazemetostat well, with several patients experiencing responses ...
Epizyme Presents Data from a Phase 1 Trial of Tazemetostat in Children with Relapsed or Refractory INI1-Negative ... GlobeNewswire (press release)

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