Drug Combo Tackling Solid Tumors 
Drug Discovery & Development
Cancer Research UK's Drug Development Office has opened the first trial of a new drug combination in patients with advanced solid tumors and in a subset of patients who have non-small cell lung cancer. This trial will combine two compounds that aim to ...
Combination of New Drug to Counter Lung Cancer TopNews Arab Emirates

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Texas Sized Results for Melanoma Drug Trial 
dailyRx
A three year trial concluded this May, that tested how effective the melanoma drug, dabrafenib is in treating advanced solid tumors, including those with metastasis. Dabrafenib works specifically in tumors with a mutation in a gene called BRAF, ...

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Novelos Therapeutics Successfully Completes First Cohort In Phase 1b Solid ... 
MarketWatch (press release)
"Patients with advanced solid tumors need safer and more effective therapies," said Dr. Liu. "Based on animal data, results from a completed Phase 1a dosimetry trial, and now initial data from this Phase 1b trial, HOT appears to deliver radiation ...
First Cohort of HOT Phase Ib in Solid Tumor Completed - Analyst Blog NASDAQ

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Melanoma Agent Surprise: Brain Tumors Shrink Too 
Medscape
May 17, 2012 ? The efficacy of the investigational cancer agent dabrafenib (GlaxoSmithKline) evidently extends beyond its targets of solid tumors and melanomas that harbor BRAF mutations, according to a phase 1 trial. The agent also reduced the size ...
ASCO: Dabrafenib/Trametinib Active in Metastatic Melanoma Doctors Lounge
Glaxo's Melanoma Cocktail Slows Cancer in Study BusinessWeek

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Dabrafenib Safe in Melanoma With Brain Mets 
MedPage Today
The authors enrolled 156 patients with incurable solid tumors including metastatic melanoma, melanoma with asymptomatic, untreated brain metastases, and nonmelanoma solid tumors. Among melanoma patients without brain metastases, 75% carried Val600Glu ...
ASCO: Dabrafenib/Trametinib active in metastatic melanoma Medical Xpress
Glaxo's Melanoma Cocktail Slows Cancer in Study Bloomberg

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First Cohort of HOT Phase Ib in Solid Tumor Completed 
Zacks.com
... Report) announced that it has successfully completed the first cohort in a US multi-center Phase Ib dose-escalation trial of its cancer-targeted molecular radiotherapeutic compound I-131-CLR1404 (HOT) in cancer patients with advanced solid tumors.
Novelos Therapeutics Successfully Completes First Cohort In Phase 1b Solid ... PR Newswire (press release)

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Novelos Therapeutics Successfully Completes First Cohort In Phase 1b Solid ... 
Sacramento Bee
"Patients with advanced solid tumors need safer and more effective therapies," said Dr. Liu. "Based on animal data, results from a completed Phase 1a dosimetry trial, and now initial data from this Phase 1b trial, HOT appears to deliver radiation ...

and more » 

ASCO: Crizotinib tolerated, active in pediatric patients 
Oncology Nurse Advisor
Yael P. Mosse, MD, from the Children's Hospital of Philadelphia, and colleagues conducted a phase 1 dose-escalation and pharmacokinetic trial of crizotinib in 70 patients with refractory solid tumors and anaplastic large cell lymphoma (ALCL).

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Peregrine Announces Positive Top-Line Data From Randomized, Double-Blind ... 
MarketWatch (press release)
Tumor responses were determined in accordance with Response Evaluation Criteria In Solid Tumors (RECIST 1.1). Patients received up to 6 cycles of docetaxel (75mg/m2) plus either placebo, 1 mg/kg bavituximab, or 3 mg/kg bavituximab until disease ...

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Genetic Profile of Circulating Tumor Cells Is Heterogeneous 
Doctors Lounge
Gene expression of circulating tumor cells, rare cells in the blood of patients with solid tumors, is heterogeneous and is distinct from the profiles of single cells from cancer cell lines commonly used to study cancer, according to a study published ...

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