Solid Tumors News

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Prognostic role of HSF1 overexpression in solid tumors: a pooled analysis of 3159 patients - Dove Medical Press



Prognostic role of HSF1 overexpression in solid tumors: a pooled analysis of 3159 patients 
Dove Medical Press
The results showed that positive HSF1 expression was significantly correlated with poor overall survival in all tumors (HR=2.09; 95% CI: 1.62?2.70; P<0.001). Subgroup analysis revealed that there was a significant association between HSF1 ...

 


Dosing underway in early-stage study of Leap's TRX518 in advanced solid tumors; shares ahead 5% premarket - Seeking Alpha



Dosing underway in early-stage study of Leap's TRX518 in advanced solid tumors; shares ahead 5% premarket 
Seeking Alpha
Thinly traded nano cap Leap Therapeutics (NASDAQ:LPTX) is up 5% premarket, albeit on only 800 shares, in response to its announcement that the first patient has been dosed in a Phase 1 clinical trial assessing GITR agonist TRX518, in combination with ...

 


Beyond CARs: New T-Cell Strategies Take Center Stage - OncLive



OncLive
 
Beyond CARs: New T-Cell Strategies Take Center Stage 
OncLive
Finding proteins on the surface of tumor cells that are not present in normal tissues has been extremely challenging?especially in the case of solid tumors?decreasing the prospects for a safe CAR therapy for solid tumors. However, another modality of ...

 


Cancer Diagnosis from a Blood Draw? Liquid Biopsies Are Still a Dream - WIRED



WIRED
 
Cancer Diagnosis from a Blood Draw? Liquid Biopsies Are Still a Dream 
WIRED
Most published studies, including this one, focus on measuring and monitoring advanced tumor stages. A few liquid biopsies have even been approved to help match tumors to targeted drugs. But the dream is to develop a simple blood test to actually ...
Life-Saving Early Cancer Detection Could Be Vastly Improved With New Blood Test Newsweek

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Aeglea BioTherapeutics to Present Preclinical Data at 2018 Keystone Symposia Tumor Metabolism Conference - GlobeNewswire (press release)



Aeglea BioTherapeutics to Present Preclinical Data at 2018 Keystone Symposia Tumor Metabolism Conference 
GlobeNewswire (press release)
In some cancers, tumors cells stop producing specific amino acids, making them vulnerable to starvation through depletion of that amino acid in the blood. Pegzilarginase is intended to address an unmet need for the treatment of arginine dependent ...

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Leap Therapeutics Announces First Patient Dosed with TRX518 Combination Therapy in Advanced Solid Tumors Trial - GlobeNewswire (press release)



Leap Therapeutics Announces First Patient Dosed with TRX518 Combination Therapy in Advanced Solid Tumors Trial 
GlobeNewswire (press release)
CAMBRIDGE, Mass., Jan. 16, 2018 (GLOBE NEWSWIRE) -- Leap Therapeutics, Inc. (Nasdaq:LPTX), a biotechnology company developing targeted and immuno-oncology therapeutics, today announced that the first patient has been dosed in a Phase 1 clinical trial ...

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Compugen Presents New Preclinical Data Demonstrating the Distinctive Features of the PVRIG Pathway in Immuno ... - Markets Insider



Compugen Presents New Preclinical Data Demonstrating the Distinctive Features of the PVRIG Pathway in Immuno ... 
Markets Insider
HOLON, Israel, Jan. 18, 2018 /PRNewswire/ -- Compugen Ltd. (NASDAQ: CGEN), a leader in predictive discovery and development of first-in-class therapeutics for cancer immunotherapy, today announced new preclinical data demonstrating distinctive features ...

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Kite, Pfizer to Assess Yescarta-Utomilumab Combination in Lymphoma - Genetic Engineering & Biotechnology News



Kite, Pfizer to Assess Yescarta-Utomilumab Combination in Lymphoma 
Genetic Engineering & Biotechnology News
Pfizer is investigating utomilumab in both hematologic cancers and solid tumors as a single agent and in combination with other anti-cancer therapies. Pfizer has also cited evidence that suggests that 4-1BB, a costimulatory protein expressed on ...
Clinical Collab to Evaluate Yescarta and Utomilumab in Large B-Cell Lymphoma Drug Discovery & Development

all 2 news articles » 


Pediatric Cancer Advisor - Cancer Therapy Advisor



Cancer Therapy Advisor
 
Pediatric Cancer Advisor 
Cancer Therapy Advisor
No dose-limiting toxicities were observed among the 6 patients who received ontuxizumab 4 mg/kg and 6 patients who received 8 mg/kg. Ontuxizumab is well-tolerated among pediatric patients with relapsed or refractory solid tumors, according to a study ...

 


Bridging tumor moats with potent drug delivery particles - Science Daily



Bridging tumor moats with potent drug delivery particles 
Science Daily
Despite herculean efforts, cancer remains a formidable disease, with each malignant subtype responding differently to therapeutics. One hurdle specific to treating solid tumors is a protective layer called an extracellular matrix that can prevent ...